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People who have a type of skin cancer known as melanoma may benefit from treatment with trametinib. This prescription drug is reserved for use when the cancer has progressed to other areas of the body or cannot be treated surgically. It comes as a tablet that is taken once a day. Potential side effects include diarrhea, a rash, and swelling of the face, arms, or legs.

What Is Trametinib?

Trametinib (Mekinist™) is a prescription medication approved to treat people with advanced melanoma, a type of skin cancer, when the cancer has spread to other parts of the body or cannot be treated with surgery. It is used when the cancer cells have a certain abnormal change in a gene known as the BRAF gene. Certain medical tests can be done to determine if the cancer cells have this abnormal gene.
Trametinib belongs to a group of medicines known as kinase inhibitors.
(Click What Is Trametinib Used For? for more information, including possible off-label uses.)

Are There Side Effects?

As with other anticancer medicines, trametinib can cause side effects, some of which can be significant. While not everyone who takes the drug will experience problems, many people will experience some type of side effect during treatment.
Common trametinib side effects include but are not limited to:
  • Rash
  • Diarrhea
  • Swelling of the face, arms, or legs.
(Click Trametinib Side Effects to learn more, including potentially serious side effects that you should report immediately to your healthcare provider.)
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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