Cancer Home > Drug Interactions With Tramadol ER

Sibutramine
Taking tramadol ER with sibutramine can cause seizures or a group of symptoms called serotonin syndrome. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome, as it can be very dangerous.
 
St. John's Wort
Taking tramadol ER with St. John's wort can cause a group of symptoms called serotonin syndrome. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome, as it can be very dangerous.
 
Triptans
Taking tramadol ER with a triptan can cause a group of symptoms called serotonin syndrome. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome, as it can be very dangerous.
 
Tryptophan
Taking tramadol ER with tryptophan can cause a group of symptoms called serotonin syndrome. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome, as it can be very dangerous.
 
Warfarin
There have been rare reports of a possible interaction between warfarin and tramadol ER. This interaction might increase your risk of bleeding. Check with your healthcare provider before combining these medications; you may need to be monitored more closely.
 

Final Thoughts on Tramadol ER Drug Interactions

It is possible that not all tramadol ER drug interactions were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about any specific drug interactions that may apply to you.
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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