The following sections explain in detail the potentially negative interactions that can occur when tramadol ER is combined with any of the drugs listed above.
You should avoid alcohol while taking tramadol ER. Alcohol interacts with tramadol ER, potentially increasing the risk of serious side effects, such as extreme drowsiness, confusion, memory loss, or difficulty breathing (see Tramadol and Alcohol for more information).
Taking cyclobenzaprine with tramadol ER increases the risk of seizures. This combination should be avoided if possible, especially in people who already have seizure problems.
Taking tramadol ER with dextromethorphan can cause a group of symptoms called serotonin syndrome. These symptoms include confusion, hallucinations, a fast heartbeat, feeling faint, fever, sweating, muscle spasms, difficulty walking, and diarrhea. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any of these symptoms, as serotonin syndrome can be very dangerous (see Tramadol and Serotonin Syndrome for more information).
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