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Clinical Effects for Toremifene

Toremifene has been studied in clinical trials that included postmenopausal women with estrogen receptor-positive or estrogen receptor-unknown metastatic breast cancer. In these studies, as many as 31.3 percent of women responded to this medication. It took a median of 4.9 to 7.3 months for the breast cancer to progress after treatment was started. Furthermore, women survived a median of 25.4 to 33.6 months while being treated with toremifene.
In all the studies, toremifene was compared to a commonly used breast cancer medication known as tamoxifen (Nolvadex®, Soltamox®). In general, toremifene was as effective as tamoxifen at treating breast cancer. However, in one study, women treated with tamoxifen went about three months longer before their cancer progressed than those treated with toremifene.

When and How to Take This Medicine

Some general considerations to keep in mind during treatment with toremifene include the following:
  • This medication comes in tablet form. It is usually taken by mouth once a day.
  • Toremifene can be taken with or without food. Try taking it with food if it seems to bother your stomach.
  • You should avoid drinking grapefruit juice while taking toremifene unless your healthcare provider tells you otherwise. Grapefruit juice may increase blood levels of this drug, increasing your risk for side effects.
  • You can take your dose any time of day, but try to take it at about the same time each day to keep an even level of the drug in your bloodstream.
  • For the medication to work properly, it must be taken as prescribed. Toremifene will not work if you stop taking it.

Dosing Information for Toremifene

There is only one standard recommended dose of toremifene, regardless of your age, weight, or other medical conditions. As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.
(Click Toremifene Dosage for more information.)
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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