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More Detail on Drug Interactions With Toremifene

The following sections explain in detail the potentially negative interactions that can occur when toremifene is combined with any of the drugs listed above.
 
Aminoglutethimide
Taking toremifene with aminoglutethimide may decrease the level of toremifene in your blood, perhaps making it less effective. Talk with your healthcare provider before taking these medicines together.
 
Clarithromycin and Telithromycin
Clarithromycin and telithromycin can increase blood levels of toremifene, possibly increasing your risk for potentially serious side effects, such as heart rhythm problems. The manufacturer of toremifene recommends it not be taken with either of these antibiotic medicines.
 
Certain Antifungal Medications
Taking toremifene with certain antifungal medicines could increase the amount of toremifene in your blood, potentially increasing your risk for serious side effects, such as heart rhythm problems. The manufacturer of toremifene recommends these drugs not be taken together.
 
Certain Antiseizure Medicines
Taking toremifene with certain antiseizure drugs (anticonvulsants) may decrease the level of toremifene in your blood, perhaps making it less effective. Talk with your healthcare provider before taking these medicines together.
 
Dexamethasone
Taking toremifene with dexamethasone may decrease the level of toremifene in your blood, perhaps making it less effective. Talk with your healthcare provider before taking these medicines together.
 
QT-Prolonging Medications
In general, toremifene should not be combined with any other medications that can cause QT prolongation (a certain change in the heart rhythm), due to the risk of a life-threatening arrhythmia. If you must take toremifene with another medication that can cause QT prolongation, your healthcare provider will need to monitor you closely for possible heart rhythm problems.
 
Nefazodone
Nefazodone can increase blood levels of toremifene, possibly increasing your risk for potentially serious side effects, such as heart rhythm problems. The manufacturer of toremifene recommends it not be taken with nefazodone.
 
Protease Inhibitors
Protease inhibitors may increase blood levels of toremifene, potentially increasing your risk for serious side effects, such as heart rhythm problems. The manufacturer of toremifene recommends these drugs not be taken together.
 
Rifamycin Antibiotics
Taking toremifene with rifamycin antibiotics may decrease the level of toremifene in your blood, perhaps making it less effective. Talk with your healthcare provider before taking these medicines together.
 
St. John's Wort
Taking toremifene with St. John's wort may decrease the level of toremifene in your blood, perhaps making it less effective. Talk with your healthcare provider before taking these medicines together.
 
Thiazide Diuretics
Taking toremifene with thiazide diuretics may increase the chance that you will develop high calcium blood levels (hypercalcemia). Talk to your healthcare provider before taking these medicines together. Your healthcare provider may need to monitor you more closely.
 
Warfarin
Toremifene may increase blood levels of warfarin, which could increase your risk for side effects, such as dangerous bleeding. If you take warfarin, your healthcare provider may choose to monitor you more closely by checking your international normalized ratio (INR), especially when you start or stop taking toremifene.
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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