Cancer Home > Drug Interactions With Thalidomide

Digoxin
Taking thalidomide and digoxin together could increase your risk for a dangerously low heartbeat (bradycardia). Your healthcare provider may choose to monitor you more closely if you take these medicines together.
 
Echinacea
Echinacea may decrease the effectiveness of thalidomide. This is because echinacea is thought to stimulate the activity of the immune system, while thalidomide suppresses the activity of the immune system. Talk to your healthcare provider before taking echinacea during thalidomide treatment.
 
Live Vaccinations
Live vaccines are vaccines that contain live viruses or bacteria. If you receive a live vaccine while taking thalidomide, you could become infected with the virus or bacteria from the vaccine. Also, live vaccines may be less effective in people taking thalidomide. Talk to your healthcare provider before receiving a vaccination during thalidomide treatment.
 
Medications That Cause Drowsiness
Because thalidomide can cause drowsiness, taking it with other medications that cause drowsiness may increase your risk for extreme sedation. You may not be able to safely drive or perform tasks that require alertness if you take thalidomide with other sedating medicines.
 
Pamidronate
Taking thalidomide with pamidronate may increase your risk for kidney problems. Although the risk for this interaction is probably quite low, your healthcare provider may choose to monitor your kidney function more closely if you take these medicines together.
 
Sipuleucel-T
Thalidomide could decrease the effectiveness of sipuleucel-T. Talk to your healthcare provider about this potential interaction before taking these medicines together.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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