Protein kinases are enzymes found in the body that regulate cell function, including cell growth. Temsirolimus works by blocking the action of a specific protein kinase called the mammalian target of rapamycin (mTOR).
When mTOR is not functioning properly, as is the case in certain types of cancer, it causes cells to grow and multiply abnormally. This enzyme also promotes blood vessel growth into tumors, which supplies cancer cells with nutrients and energy, and gives them a way to spread to other areas of the body.
By blocking the action of mTOR, temsirolimus may slow down the growth of cancer and tumor cells. It also cuts off the blood supply to cancer cells, which may help slow down the spread of the cancer.
Can Children Use Temsirolimus?
This medication is not approved for use in children, as it has not been adequately studied in this age group. Talk to your child's healthcare provider about the risks and benefits of using temsirolimus in children.
Is It Safe for Older Adults?
Temsirolimus can be used in older adults. In clinical studies, older adults were more likely to experience certain temsirolimus side effects, including diarrhea, edema (water retention or swelling), and pneumonia. Speak with your healthcare provider if these side effects are a concern for you.
Are There Off-Label Reasons to Use Temsirolimus?
On occasion, your healthcare provider may recommend this medicine for treating something other than advanced RCC. This is called an "off-label" use. Temsirolimus may sometimes be used off-label to treat mantle cell lymphoma, a type of non-Hodgkin's lymphoma.
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