Cancer Home > Sipuleucel-T

Sipuleucel-T is prescribed to treat prostate cancer that does not respond to certain types of cancer treatment. It works by using the body's own immune cells to attack the prostate cancer cells. It is administered by your healthcare provider using an intravenous infusion, and is given every two weeks for a total of three doses. Potential side effects may include fatigue and chills.

What Is Sipuleucel-T?

Sipuleucel-T (PROVENGE®) is a prescription medication approved to treat prostate cancer. It is used in men who have not responded to certain other prostate cancer treatments and have minimal or no prostate cancer symptoms.
Sipuleucel-T is considered an autologous (obtained from you) cellular immunotherapy. This means it is made from a person's own immune cells. The cells are mixed with an active protein designed to help stimulate an immune response to prostate cancer.
Sipuleucel-T is sometimes called a prostate cancer vaccine because it activates the immune system. Unlike vaccines used to prevent diseases, sipuleucel-T is used to treat prostate cancer that already exists in the body. It is not used to prevent prostate cancer.
(Click What Is Sipuleucel-T Used For? for more information, including possible off-label uses.)

Are There Side Effects?

Just like any medicine, sipuleucel-T may cause side effects. However, not everyone who receives the drug will experience problems. In fact, most people tolerate it quite well.
If reactions do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider. Serious side effects are less common.
Common side effects of sipuleucel-T include but are not limited to:
(Click Sipuleucel-T Side Effects to learn more, including potentially serious side effects you should report immediately to your healthcare provider.)
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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