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Sancuso is a medication licensed for preventing nausea and vomiting due to chemotherapy. This prescription medication comes in the form of a patch that is applied to the skin 24 to 48 hours before chemotherapy treatment begins. It is absorbed through the skin into the bloodstream, providing around-the-clock medication. The most common side effect of Sancuso is constipation.

What Is Sancuso?

Sancuso® (granisetron transdermal) is a prescription medication that comes in the form of a skin patch. It is approved to prevent nausea and vomiting due to chemotherapy (known as chemotherapy-induced nausea and vomiting, or CINV).
 
(Click Sancuso Uses for more information on what the medication is used for, including possible off-label uses.)
 

Who Makes It?

Sancuso is made by Aveva Drug Delivery Systems, Inc. and is marketed and distributed by ProStrakan, Inc.
 

How Does It Work?

Nausea and vomiting are complex processes involving many chemicals in the body and several parts of the body, including the brain and the small intestine. It is likely that Sancuso works in the small intestine, but it may also work in the brain.
 
The medication works by blocking serotonin, a chemical produced by the body that is associated with nausea and vomiting. Serotonin has many effects in the body and has several receptors where it can bind. It blocks serotonin at a specific type of receptor (the 5-HT3 receptor), which is important for nausea and vomiting. Sancuso has no effects on other types of serotonin receptors in the body.
 
As mentioned, the medication comes in the form of a skin patch. It is absorbed through the skin into the bloodstream, providing around-the-clock medication, helping to prevent nausea and vomiting without the need for swallowing capsules or tablets (which can be difficult for people fighting nausea and vomiting).
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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