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Regorafenib is used for slowing down the growth of colorectal cancer that has spread to other areas of the body. This prescription chemotherapy drug works by disrupting the growth and division of cancer cells. It comes as a tablet that is taken once daily. Most people taking this medication will develop some type of side effect, such as fatigue, diarrhea, or decreased appetite.

What Is Regorafenib?

Regorafenib (Stivarga®) is a prescription medication approved to treat colorectal cancer (cancer of the colon and rectum) that has spread to other areas of the body. It is used when the cancer has progressed after treatment with other chemotherapy. Regorafenib belongs to a group of medicines known as multikinase inhibitors.
(Click What Is Regorafenib Used For? for more information on this topic, including possible off-label uses.)

Are There Side Effects?

Just like any chemotherapy medicine, regorafenib can cause side effects, some of which can be significant and potentially serious. In fact, most people will experience some type of side effect during treatment. Talk with your healthcare provider about ways to prevent or lessen reactions to this drug.
Some of the more common side effects seen with regorafenib include but are not limited to:
  • Weakness, lack of strength, and fatigue
  • Decreased appetite
  • Redness, pain, or blisters on the skin
  • Diarrhea
  • Mouth sores and inflammation.
(Click Regorafenib Side Effects to learn more, including potentially serious side effects you should report immediately to your healthcare provider.)
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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