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Clinical Effects of Regorafenib

Regorafenib has been shown to help people with colorectal cancer live longer. In one clinical study, people who had colorectal cancer that had spread to other areas of the body were randomly assigned to take regorafenib or a placebo (a "sugar pill" that does not contain any active ingredients).
In this study, people who took regorafenib lived a median of 6.4 months (the median is the middle number of a group, meaning half the people survived less than 6.4 months, while half survived longer than 6.4 months). In comparison, people who took the placebo lived a median of 5 months.
In addition, those receiving regorafenib lived two months without their tumors growing (this is known as progression-free survival). People receiving the placebo lived 1.7 months without tumor growth.

When and How to Take This Medicine

Some general considerations to keep in mind during treatment with regorafenib include the following:
  • This medication comes in the form of a tablet. It is usually taken by mouth once a day in the morning.
  • Regorafenib should be taken with a low-fat breakfast that contains less than 30 percent fat.
  • You should take your dose at the same time each day to keep an even level of the drug in your bloodstream.
  • Do not cut, crush, or break regorafenib tablets; make sure to swallow them whole.
  • Do not drink grapefruit juice while taking this medication, as it may increase the amount of regorafenib in your body.
  • For this drug to work properly, it must be taken as prescribed. Do not stop taking it just because you feel better.

Dosing Information

The dose of regorafenib your healthcare provider recommends may vary, depending on how you tolerate the medication. As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.
(Click Regorafenib Dosage for more information.)
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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