Cancer Home > Propoxyphene Napsylate Dosage

For treating pain, the typical recommended dosage of propoxyphene napsylate is one tablet taken every four hours as needed. However, it is important to not take more than six tablets in a 24-hour period. Depending on how you respond to this pain reliever, other medications you are taking, and other medical conditions you may have, your healthcare provider may need to adjust your dosage.

An Introduction to Dosing With Propoxyphene Napsylate

In November 2010, the United States Food and Drug Administration (FDA) withdrew all medications that contain propoxyphene from the market. It has been determined that the risks of propoxyphene outweigh the possible benefits. In particular, the FDA was concerned about the drug's ability to cause serious changes in the heart rhythm, even at normal doses. Pharmacies will no longer sell this medication, and people who take it should stop and ask their healthcare provider for a more suitable pain medication.
 
The dose of propoxyphene napsylate (Darvon-N®) your healthcare provider recommends will vary, depending on a number of factors, including:
 
  • Other medications you are taking
  • How you respond to propoxyphene napsylate
  • Other medical conditions you may have.
     
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.
 

Propoxyphene Napsylate Dosage for Pain

The standard recommended dose of propoxyphene napsylate for treating pain is one tablet (100 mg) every four hours as needed. Do not take more than six tablets in 24 hours.
 
Each propoxyphene napsylate (Darvon-N) 100-mg tablet contains the same amount of medication as one 65-mg Darvon® (propoxyphene hydrochloride) capsule, due to differences between the molecular weights of the active ingredients.
 
If you have been taking propoxyphene napsylate on a long-term basis, it is best to stop taking it gradually, under the supervision of a healthcare provider. Stopping it too quickly could lead to unpleasant (although rarely dangerous) withdrawal symptoms. Typically, decreasing the dosage by 25 to 50 percent each day works well.
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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