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Common Side Effects

Ponatinib has been studied extensively in clinical trials. In these studies, the side effects that occurred in a group of people taking the drug were carefully documented. As a result, it was possible to see what side effects occurred and how often they appeared.
In these studies, the most common ponatinib side effects included:
  • High blood pressure (hypertension) -- in up to 71 percent of people
  • A rash -- up to 54 percent
  • Abdominal (stomach) pain -- up to 49 percent
  • Constipation -- up to 47 percent
  • Headache -- up to 39 percent
  • Fatigue -- up to 39 percent
  • Dry skin -- up to 39 percent
  • Nausea -- up to 32 percent
  • Fever -- up to 32 percent
  • Decreased appetite -- up to 31 percent
  • Blood clots -- up to 27 percent.
A variety of laboratory abnormalities (typically found using blood tests) were also a common occurrence. Some were quite serious, such as low blood counts.
Other common reactions, occurring in 21 percent to 26 percent of people, included:
  • Diarrhea
  • Joint pain
  • Fever, along with low white blood cells ("febrile neutropenia")
  • Vomiting
  • Mouth sores
  • A severe and dangerous response to an infection ("sepsis")
  • Muscle pain
  • Swelling and water retention in the arms and legs
  • Shortness of breath.

Final Thoughts

You may experience some or none of the side effects listed in this article. Unfortunately, there is no way for your healthcare provider to know beforehand if you will have problems with a medicine that you have never tried.
Therefore, make sure to let your healthcare provider know if you develop any side effects while taking ponatinib or if something "just does not seem right." While it may not be related to the medication, your healthcare provider will be able to diagnose and treat the problem.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
List of references (click here):
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