Cancer Home > Ponatinib
You should talk with your healthcare provider prior to taking this medication if you have:
- Liver disease, such as hepatitis, cirrhosis, or liver failure
- Ever had a blood clot or stroke
- Heart problems of any kind
- High blood pressure (hypertension)
- Ever had pancreatitis
- An upcoming surgery
- Any allergies, including to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
- A frequent alcohol drinker
- Pregnant or thinking of becoming pregnant (see Iclusig and Pregnancy)
- Breastfeeding (see Iclusig and Breastfeeding).
Make sure to tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
(Click Precautions and Warnings With Ponatinib to learn more, including information on who should not take the drug.)
Ponatinib belongs to a group of medicines known as tyrosine kinase inhibitors. Tyrosine kinases are proteins found in the body that control cell function, including cell growth. Ponatinib works by blocking the signal of certain tyrosine kinases, including but not limited to:
- A mutated kinase known as T315I mutant ABL
- A kinase that is resistant to treatment with other tyrosine kinase inhibitors.
By inhibiting the activity of T315I mutant ABL and other kinases, ponatinib slows down or stops the production of the abnormal blood cells.