Cancer Home > Pertuzumab Side Effects

Some people who receive pertuzumab will develop side effects during treatment. Some of the most commonly reported reactions include fatigue, diarrhea, and hair loss. There are also some potentially serious problems that can occur, such as unexplained swelling, hives, or vomiting. Because it is difficult to predict whether you will have problems, let your healthcare provider know if you develop anything that "just doesn't seem right."

An Introduction to Side Effects of Pertuzumab

Just like any medicine, pertuzumab (Perjeta™) can cause side effects. However, not everyone who uses the drug will have problems. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with pertuzumab. Your healthcare provider can discuss a more complete list with you.)

Serious Pertuzumab Side Effects

Some side effects of pertuzumab are potentially serious and should be reported immediately to your healthcare provider. These include but are not limited to:
  • Signs of congestive heart failure, including difficulty breathing and swelling or water retention
  • Signs of an allergic reaction, such as:
    • An unexplained rash
    • Hives
    • Itching
    • Unexplained swelling, especially of the mouth, lips, or throat
    • Wheezing
    • Difficulty breathing or swallowing.
Let your healthcare provider know immediately if you notice any signs of an infusion reaction while the medication is being administered. Signs of an infusion reaction to pertuzumab might include:
  • Nausea
  • Vomiting
  • Pain
  • Headache
  • Dizziness
  • Shortness of breath
  • Low blood pressure
  • A rash
  • A general feeling of weakness.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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