If you miss a dose of pazopanib, take it as soon as you remember, as long as it is at least 12 hours until your next scheduled dose. If your next dose is less than 12 hours away, simply skip your missed dose and continue with your regular schedule.
How Does This Drug Work?
Pazopanib works by blocking an enzyme in the body known as tyrosine kinase. This enzyme tells cancer cells to grow and divide. By blocking tyrosine kinase, pazopanib may slow down the growth of cancer cells.
In clinical studies, pazopanib improved "progression-free survival" (PFS), which is the period of time the cancer does not get worse. In one study, people with advanced kidney cancer who took pazopanib had an average of 9.2 months of PFS, compared with 4.2 months in people taking a placebo (a "sugar pill" that does not contain any active ingredients). In another study, people with soft tissue cancer experienced an average of 4.6 months of PFS, while people given a placebo had 1.6 months of PFS.
Written by/reviewed by: Kristi Monson, PharmD;Arthur Schoenstadt, MD
Last reviewed by: KristiMonson, PharmD;
List of references (click here):
Votrient [package insert]. Research Triangle Park, NC: GlaxoSmithKline;2013 August.
Food and Drug Administration, Center for Drug Evaluation and Research. Electronic orange book: approved drug products with therapeutic equivalence evaluations. FDA Web site. Available at: http://www.fda.gov/cder/ob/. Accessed October 7, 2011.
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