Cancer Home > Drug Interactions With Pazopanib
More Detail on Drug Interactions With PazopanibThe following sections explain in detail the potentially negative interactions that can occur when pazopanib is combined with any of the drugs listed above.
CYP 3A4 Inducer Medications
The liver breaks down pazopanib using enzymes known as CYP 3A4 enzymes. Medications known as CYP 3A4 inducers can increase the activity of these enzymes. Combining pazopanib with one of these drugs may decrease the level of pazopanib in your bloodstream, potentially making it less effective. It is generally recommended that pazopanib not be combined with the CYP 3A4 inducers listed in this article.
CYP 3A4 Inhibitor Medications
The liver breaks down pazopanib using enzymes known as CYP 3A4 enzymes. Medications known as CYP 3A4 inhibitors can decrease the activity of these enzymes. Combining pazopanib with one of these drugs may increase the level of pazopanib in your bloodstream, potentially increasing your risk for side effects.
If you take pazopanib with strong CYP 3A4 inhibitors, your healthcare provider may need to reduce your pazopanib dosage to 400 mg a day, or possibly even lower.
Taking denosumab with pazopanib could increase your risk for potentially serious infections. Talk to your healthcare provider before taking these medicines together. Also, contact your healthcare provider if you develop any symptoms of an infection, such as fever, chills, aches and pains, or coughing.
Pazopanib may be less effective if it is taken with echinacea. Do not take these medications together unless your healthcare provider tells you otherwise.
Drinking grapefruit juice with pazopanib may increase the level of pazopanib in your body, possibly increasing your risk for side effects. To avoid this interaction, do not drink grapefruit juice while taking pazopanib.