Cancer Home > Oxymorphone ER Dosage

A person's individualized dose of oxymorphone ER will be based on the type and severity of the pain, previous painkillers taken, and other existing medical conditions, among other factors. Available as an extended-release tablet, this product only needs to be taken twice daily, with 12 hours between each dose. Do not take this pain medication on an "as-needed" basis.

An Introduction to Your Dosage of Oxymorphone ER

The dosage of oxymorphone ER (Opana® ER) your healthcare provider recommends will vary, depending on a number of factors, including:
  • How you respond to oxymorphone ER
  • The type and dose of other painkillers you have taken
  • The type and severity of your pain
  • Other medications you are taking
  • Other medical conditions you may have.
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.

Oxymorphone ER Dosing Guidelines

Oxymorphone ER is usually given twice a day (every 12 hours) in equal doses. However, some people may benefit from a larger dose in the morning or at night, depending on their particular patterns of pain.
The starting dose of oxymorphone ER your healthcare provider recommends will depend mostly on the dose and type of painkillers you were previously taking. For immediate-release oral oxymorphone (Opana®), a straight mg-per-mg conversion is recommended. Simply add up the total mg of oxymorphone you take each day and divide by two; this is the recommended oxymorphone ER dose given every 12 hours.
If you are switching from non-oxymorphone painkillers or from injected oxymorphone, your healthcare provider will need to convert your current dosage to an appropriate oxymorphone ER dosage. It is often best to slightly underestimate the dosage initially, in order to avoid dangerous oxymorphone ER side effects.
Your healthcare provider may also recommend a "rescue" medication (a short-acting painkiller) to use in addition to oxymorphone ER. This short-acting pain reliever is used when your pain is especially severe; this is called "breakthrough pain," as it breaks through your baseline, long-acting painkiller. A rescue medication can be especially useful when you are first starting oxymorphone ER, as many healthcare providers underestimate your initial oxymorphone requirement to avoid dangerous side effects.
If you are unaccustomed to opioid medications, the usual starting dosage of oxymorphone ER is low and typically starts at 5 mg twice daily.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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