Cancer Home > Drug Interactions With Oxymorphone ER

There are numerous products that can cause negative drug interactions with oxymorphone ER, including antidepressants, muscle relaxants, and even alcohol. These reactions could increase your risk for serious side effects, such as confusion, difficulty passing urine, and breathing problems. To reduce your risk for complications, tell your healthcare provider about all other medications you are taking, including nonprescription medications and herbal supplements.

An Overview of Oxymorphone ER Interactions

Oxymorphone ER (Opana® ER) may interact with a number of other medications. Some of the drugs that can lead to reactions with oxymorphone ER include but are not limited to:
  • Alcoholic beverages
  • Alvimopan (Entereg®)
  • Antidepressants
  • Antihistamines (including many nonprescription cold, cough, allergy, motion sickness, and sleep medications)
  • Anticholinergic medications, such as:
  • Barbiturates, such as:
    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)
  • Benzodiazepine sedatives, such as:
  • Muscle relaxants, such as:
  • Monoamine oxidase inhibitors (MAOIs), such as:
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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