Cancer Home > Oxaliplatin Side Effects

Among the most commonly reported side effects of oxaliplatin are nerve problems, vomiting, and hair loss. Although some of these problems are minor and treated easily, there are some potentially serious complications that require immediate medical treatment. Seek medical attention right away if you develop a sudden cough, seizures, or other potentially serious reactions.

An Introduction to Side Effects of Oxaliplatin

As with other chemotherapy medicines, oxaliplatin (Eloxatin®) can cause side effects, some of which can be severe. In fact, most people will experience some type of side effect during oxaliplatin treatment. Talk to your healthcare provider about strategies to prevent or treat side effects you may experience.
(This article covers many, but not all, of the possible side effects with oxaliplatin. Your healthcare provider can discuss a more complete list with you.)

Serious Oxaliplatin Side Effects

Some oxaliplatin side effects are potentially serious and should be reported immediately to your healthcare provider. These include but are not limited to:
  • Signs of an allergic reaction or an infusion reaction (a reaction that happens while receiving or soon after your dose), such as:
    • Rash
    • Flushing of the face
    • Hives
    • Itching
    • Dizziness or fainting
    • Swelling of the mouth, tongue, face, lips, or throat
    • Difficulty breathing or swallowing
    • Sudden cough
    • Sweating
    • Chest pain
  • Signs of nerve problems, such as:
    • Extreme sensitivity to cold temperatures and objects
    • Problems breathing or swallowing
    • Chest pressure
    • Unusual feelings in the tongue
    • Difficulty talking
    • Jaw tightness
    • Numbness, tingling, pricking, pain, or burning sensations in the hands, feet, mouth, or throat
    • Difficulty walking or doing other activities
  • Severe skin problems, such as:
    • Rash
    • Peeling
    • Severely dry skin
    • Redness
    • Swelling
  • Persistent or severe redness, swelling, pain, or bleeding at the site of the injection
  • Sores, blisters, pain, or swelling in the mouth
  • Any signs of a serious brain problem known as reversible posterior leukoencephalopathy, such as:
  • Signs of infection, such as:
    • Fever
    • Chills
    • Aches and pains
    • Coughing
    • Sore throat
    • Painful urination
  • Warmth, redness, swelling, or pain in one or both legs
  • Persistent diarrhea or vomiting
  • Signs of dehydration, such as:
    • Thirst
    • Dry mouth and lips
    • Lightheadedness
    • Less frequent urination
  • Problems breathing, shortness of breath, or a new or worse cough
  • Unusual bleeding or bruising
  • Unusual tiredness, lack of energy, or dizziness
  • Blood in the stool (which may appear as black, tarry stools)
  • Yellowing of the skin or whites of the eyes (jaundice).
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
List of references (click here):
Other Articles in This eMedTV Presentation




Related Channels

eMedTV Links
Copyright © 2006-2020 Clinaero, Inc.

eMedTV serves only as an informational resource. This site does not dispense medical advice or advice of any kind. Site users seeking medical advice about their specific situation should consult with their own physician. Click Terms of Use for more information.

This site complies with the HONcode standard for trustworthy health information:
verify here.