Cancer Home > Oxaliplatin Side Effects

Common Side Effects

Oxaliplatin has been studied extensively in clinical trials. In these studies, the side effects that occurred in people receiving oxaliplatin in combination with other chemotherapy drugs were carefully documented. As a result, it was possible to see what side effects occurred and how often they appeared.
In these studies, the most common oxaliplatin side effects included:
Other common side effects, occurring in 5 percent to 39 percent of people, included:
  • Abdominal (stomach) pain
  • Decreased appetite
  • Cough
  • Skin problems (see Skin and Nail Problems With Chemotherapy)
  • Constipation (see Constipation With Chemotherapy)
  • Fever
  • Infection
  • Nosebleeds
  • Muscle and joint pains
  • Back pain
  • General body pain
  • High blood glucose (blood sugar)
  • Swelling of the arms, hands, legs, ankles, feet, or other body areas
  • Dehydration
  • Changes in taste
  • Reactions at the site of the injection
  • Allergic reactions
  • Symptoms of the common cold, such as sore throat, runny nose, or congestion
  • Weight gain or loss
  • Rash
  • Dry or itching skin
  • Sudden warmth or redness of the face and neck
  • Depression
  • Dizziness
  • Anxiety
  • Insomnia
  • Conjunctivitis (inflammation of the conjunctiva, the membrane that lines the eyelids)
  • Gas
  • Heartburn or indigestion
  • Coldness and shivering with a fever
  • Headache
  • Redness, tenderness, or peeling of the hands or feet
  • Blood clots
  • Shortness of breath
  • Difficulty swallowing
  • Sweating
  • Increased need to urinate, painful urination, or blood in the urine
  • Vision problems
  • Nerve pain
  • Low blood pressure (hypotension)
  • Hiccups
  • Watery eyes
  • Chest pain (angina).
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
List of references (click here):
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