Cancer Home > Oxaliplatin Dosage

Prior to prescribing a specific oxaliplatin dosage, your healthcare provider will take into consideration your weight, height, and kidney function. This medication comes as an injection that is given intravenously by your healthcare provider every 14 days. You may receive these doses for six months or more, depending on whether your cancer progresses or significant side effects occur.

An Introduction to Your Dosage of Oxaliplatin

The dose of oxaliplatin (Eloxatin®) your healthcare provider recommends will vary, depending on:
  • Your height and weight
  • How you tolerate the medication
  • Your kidney function.
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.

Oxaliplatin Dosing Guidelines

The standard dosage of oxaliplatin for the treatment of colon and rectal cancer is based on body surface area, which is normally calculated using height and weight. Dosing that is based on body surface area is expressed as milligrams per meters squared, or mg per m2. The specific recommended dose of oxaliplatin is 85 mg per m2, given every two weeks. The recommended dosage for people with severe kidney disease is oxaliplatin 65 mg per m2.
Oxaliplatin is given in combination with two other chemotherapy medications: leucovorin and 5-fluorouracil (Adrucil®, Carac®, Efudex®, Fluoroplex®, also known as 5-FU). You will be given these medicines over two days, as follows:
  • Day 1: You will receive oxaliplatin and leucovorin over a two-hour period. Immediately afterward, you will receive two doses of 5-fluorouracil -- the first one is given within minutes, while the second is given over 22 hours.
  • Day 2: You will be given leucovorin and 5-FU only, in the same way you received them on day one. However, you will not receive oxaliplatin; it is only given on day one.
This two-day treatment regimen will be repeated in 14 days. The recommended length of treatment is six months in people with stage III colon cancer. People with advanced colorectal cancer will usually continue treatment until the cancer progresses or unacceptable side effects occur.
If you experience reactions during the oxaliplatin infusion, your healthcare provider may recommend you receive your dosage more slowly (for example, over six hours instead of two). Also, he or she may recommend a lower dosage for you if you experience certain serious side effects, such as nerve problems or low blood cell counts.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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