Cancer Home > Onsolis Drug Interactions

Several products can cause negative drug interactions with Onsolis, including antidepressants, alcohol, and grapefruit juice. Some of these interactions could increase your risk for serious side effects, such as drowsiness, confusion, or difficulty breathing. To ensure a safe treatment process with Onsolis, tell your healthcare provider about any other medications you are taking, including nonprescription medicines and herbal supplements.

An Overview of Interactions With Onsolis

Onsolis™ (fentanyl buccal soluble film) is a prescription narcotic pain medication used to treat breakthrough pain in people with cancer. It may interact with many other medications.
Some of the drugs that may interact with Onsolis include but are not limited to:
  • Alcohol
  • Alvimopan (Entereg®)
  • Amphetamines or amphetamine-like medications, such as:
  • CYP 3A4 inducer medications, such as:
  • CYP 3A4 inhibitor medications, such as:
  • Desmopressin (DDAVP®, Minirin®, Stimate®)
  • Grapefruit juice
  • Medications that cause drowsiness, such as:
  • Monoamine oxidase inhibitors (MAOIs), such as:
  • Octreotide (Sandostatin®)
  • Pegvisomant (Somavert®)
  • Thiazide diuretics (and thiazide-like diuretics), such as:
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
List of references (click here):
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