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Onsolis Drug Interactions ExplainedThe following sections explain in detail the potentially negative interactions that can occur when Onsolis is combined with any of the drugs listed above.
Consuming alcohol while using Onsolis could increase your risk for serious side effects, including extreme drowsiness, confusion, or breathing problems. You should avoid alcohol while using this medication.
Onsolis may increase the risk for serious alvimopan side effects. Do not take alvimopan if you have used Onsolis in the past seven days.
Combining amphetamines with Onsolis may increase the pain-relieving effects of Onsolis. Your healthcare provider may choose to monitor your response to Onsolis if you use these medications together. You might need a lower Onsolis dosage.
Using Onsolis with a beta blocker may decrease in your heart rate and blood pressure to potentially unsafe levels. If you must use these medications together, your healthcare provider may need to monitor your blood pressure and heart rate more closely.
Calcium Channel Blockers
Using Onsolis with certain calcium channel blockers may cause your heart rate and blood pressure to decrease to potentially unsafe levels. Your healthcare provider may need to monitor your blood pressure and heart rate more closely if you must use these medications together.
CYP 3A4 Inducer Medications
The body breaks down Onsolis using enzymes in the liver known as CYP 3A4 enzymes. Medications known as CYP 3A4 inducers can increase the activity of these enzymes. Combining Onsolis with one of these drugs may decrease the level of Onsolis in your body, making it less effective. Your healthcare provider may need to monitor you more closely to make sure your pain is adequately controlled if you use these medications together.