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Adults who have chronic myeloid leukemia (CML) may benefit from treatment with omacetaxine. This prescription drug is reserved for use after at least two other medications have been unsuccessful. It is given as an injection just under the skin twice daily for 7 to 14 days. Your dosage will depend on your height and weight, among other factors.


What Is Omacetaxine?

Omacetaxine mepesuccinate (Synribo™) is a prescription medication approved for the treatment of chronic myeloid leukemia (also known as chronic myelogenous leukemia, or simply CML), a type of cancer of the blood and bone marrow.
Omacetaxine is used in people who have already received at least two medications in a class of drugs known as tyrosine kinase inhibitors. It is recommended when the leukemia has progressed, despite the other treatment, or when the treatment could not be tolerated.
(Click What Is Omacetaxine Used For? for more information on this topic, including possible off-label uses.)

Are There Side Effects?

Just like any chemotherapy medicine, omacetaxine can cause side effects, some of which can be significant and potentially serious. Talk with your healthcare provider about ways to prevent or lessen reactions to this drug.
Possible side effects of omacetaxine include but are not limited to:
  • Decrease in white blood cells, which could increase the risk for infections
  • Decrease in red blood cells, which could cause anemia
  • Decrease in platelets, which could increase the risk for bleeding
  • Diarrhea
  • Fatigue.
(Click Omacetaxine Side Effects to learn more, including potentially serious side effects you should report immediately to your healthcare provider.)
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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