Cancer Home > Omacetaxine Side Effects

Some of the possible side effects of omacetaxine include nausea, diarrhea, and a loss of energy. Studies have shown that most people who use this drug will develop some type of reaction. Because omacetaxine is associated with potentially serious problems, such as dangerous infections and unusual bleeding, let your healthcare provider know immediately if you develop something that doesn't seem right.

An Introduction to Side Effects of Omacetaxine

As with any chemotherapy medicine, omacetaxine mepesuccinate (Synribo™) can cause side effects. In fact, most people will experience some type of reaction to this drug, and some problems can be quite significant. Talk to your healthcare provider about ways to prevent or lessen reactions to this medicine.
(This article covers many, but not all, of the possible side effects with omacetaxine. Your healthcare provider can discuss a more complete list with you.)

Serious Omacetaxine Side Effects

Some side effects of omacetaxine are potentially serious and should be reported to your healthcare provider right away. These include but are not limited to:
  • Signs of an infection, such as:
  • Signs of anemia, such as:
    • Weakness
    • Fatigue
    • Pale skin
    • Shortness of breath
    • Dizziness
  • Any unusual bleeding or bruising
  • Black, tarry, or bloody stools
  • Blood in the urine
  • Persistent or severe nausea, vomiting, diarrhea, or constipation
  • Signs of high blood sugar, such as:
    • Increased thirst
    • Blurred vision
    • Trouble concentrating
    • Frequent urination
  • Unexplained weight gain
  • Swelling of the arms, hands, legs, ankles, or feet
  • Redness, pain, swelling, or irritation at the injection site
  • A sudden severe headache
  • Difficulty speaking or understanding speech
  • Confusion
  • Weakness in an arm or leg
  • Loss of balance or coordination
  • Changes in vision, such as blurred vision or decreased sight
  • Yellowing of the skin or whites of the eyes (jaundice)
  • A fast, irregular, or forcefully beating heart
  • Chest pain
  • Sores in the mouth or throat
  • Seizure
  • Severe or worsening skin rash or itching
  • Signs of an allergic reaction, such as:
    • An unexplained rash
    • Hives
    • Itching
    • Swelling of the mouth or throat
    • Wheezing
    • Difficulty breathing.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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