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Nolvadex Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Nolvadex is combined with any of the drugs listed above.
 
Aminoglutethimide
Taking Nolvadex with aminoglutethimide may decrease the level of Nolvadex in your blood, perhaps making it less effective. Your healthcare provider may need to increase your Nolvadex dosage to prevent this interaction from occurring.
 
Anastrozole
Nolvadex can decrease the level of anastrozole in your blood, perhaps making it less effective. The manufacturer of Nolvadex states that these two medications should not be taken together.
 
Bromocriptine
Bromocriptine can increase the level of Nolvadex in your blood, increasing your risk for Nolvadex side effects. Your healthcare provider may need to decrease your dose of Nolvadex to prevent this drug interaction from occurring.
 
Certain Anticonvulsants
Taking Nolvadex with certain anticonvulsants may decrease the level of Nolvadex in your blood, perhaps making it less effective. Your healthcare provider may need to increase your Nolvadex dosage to prevent this.
 
Chemotherapy Medications
Combining Nolvadex with chemotherapy medications may increase the risk of blood clots. Talk to your healthcare provider about the risks and benefits of combining these medications in your particular situation.
 
Estrogens
Estrogens may decrease the effectiveness of Nolvadex. Therefore, estrogens should not be taken with this drug.
 
Letrozole
Nolvadex can decrease the level of letrozole in your blood, perhaps making it less effective. Your healthcare provider may need to increase your letrozole dosage to prevent this drug interaction from occurring.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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