Cancer Home > Drug Interactions With Nilotinib

CYP 3A4 Inhibitor Medications
The liver breaks down nilotinib using enzymes known as CYP 3A4 enzymes. Certain medications known as CYP 3A4 inhibitors can decrease the activity of these enzymes. Combining nilotinib with one of these CYP 3A4 inhibitors may increase the level of nilotinib in your bloodstream, potentially increasing your risk for serious side effects.
It is generally recommended that nilotinib not be combined with strong CYP 3A4 inhibitors. If these medicines are taken together, your healthcare provider may choose to give you a lower nilotinib dose.
Nilotinib may increase the level of dabigatran in your blood, potentially increasing your risk for bleeding. Your healthcare provider may need to lower your dabigatran dose if you take it with nilotinib.
Nilotinib may be less effective if taken with echinacea. Do not take these medications together unless your healthcare provider tells you otherwise.
Nilotinib may increase the level of everolimus in your blood, potentially increasing your risk for everolimus side effects. Your healthcare provider may need to lower your everolimus dose if you take these medications together.
H2 blockers
H2 blockers decrease the amount of nilotinib absorbed from the stomach into the bloodstream. This could make nilotinib less effective. The best way to handle this interaction is to take your H2 blocker two hours after your nilotinib dose, which should be 10 hours before your next nilotinib dose, since this medication is taken every 12 hours.
Combining leflunomide and nilotinib may increase your risk for blood cell problems, including abnormally low red blood cells, white blood cells, and platelets. Your healthcare provider will monitor you for these side effects during treatment.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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