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More Detail on Drug Interactions With Nilotinib

The following sections explain in detail the potentially negative reactions that can occur when nilotinib is combined with any of the drugs listed above.
Antacids may decrease the amount of nilotinib absorbed from your stomach into your bloodstream, potentially making it less effective. If you use antacids, take it at least two hours before or two hours after your nilotinib dose.
Certain Antidepressants
Nilotinib may increase blood levels of certain antidepressants, possibly increasing your risk for side effects. Talk to your healthcare provider about this potential interaction.
Certain Blood Pressure Medications
Nilotinib may increase blood levels of certain blood pressure medications. If you take a blood pressure medicine with nilotinib, your healthcare provider may choose to monitor your blood pressure more closely and decrease the dosage of your blood pressure medicine if needed.
Certain Diabetes Medicines
Nilotinib can increase the blood level of certain oral medicines used in the treatment of diabetes. If you take one of these diabetes medicines with nilotinib, your healthcare provider may recommend you check your blood glucose (blood sugar) levels more often, especially when you first start taking the medications together.
Nilotinib increases blood levels of colchicine, which could increase your risk for potentially serious colchicine side effects. Do not take these medications together without first talking to your healthcare provider. You may need a lower colchicine dose.
CYP 3A4 Inducer Medications
The liver breaks down nilotinib using enzymes known as CYP 3A4 enzymes. Certain medications known as CYP 3A4 inducers can increase the activity of these enzymes. Combining nilotinib with one of these CYP 3A4 inducers may decrease the level of nilotinib in your bloodstream, potentially making it less effective. It is generally recommended that nilotinib not be combined with strong CYP 3A4 inducers.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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