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Neupogen is a medicine that stimulates the production of neutrophils to help prevent infections in people receiving bone marrow transplants or undergoing chemotherapy. The drug can also aid in the collection of stem cells collected for transplantation. Neupogen is available by prescription and comes as an injection. Possible side effects include bloody nose, bone pain, and nausea or vomiting.

What Is Neupogen?

Neupogen® (filgrastim) is a prescription medication used to stimulate the production of neutrophils, which are a certain type of white blood cell important for preventing infections. Specifically, it is approved to:
  • Prevent infections in people undergoing chemotherapy
  • Prevent infections in people receiving bone marrow transplants
  • Aid in the collection of stem cells collected for use in stem cell transplantation
  • Prevent infections and other problems in people with low neutrophils due to certain other causes.
(Click Neupogen Uses for more information on what the drug is used for, including possible off-label uses.)

Who Makes It?

Neupogen is made by Amgen, Inc.

How Does Neupogen Work?

Neupogen works by stimulating the production of a certain type of white blood cell called neutrophils. Neutrophils help protect the body from infection, and having a low neutrophil count (known medically as neutropenia) increases the risk of infection. Chemotherapy (including chemotherapy during bone marrow transplantation) often causes neutropenia and infections. Some people are born with a decreased ability to produce neutrophils or stop making neutrophils due to unknown reasons, and Neupogen is also useful for increasing neutrophils in such individuals. Lastly, the drug is useful for stimulating the production of stem cells in the blood that can be collected for stem cell transplantation.
Neupogen belongs to a group of medications called granulocyte colony-stimulating factors. Colony-stimulating factors bind to stem cells in the bone marrow, stimulating the production of blood cells. Granulocyte colony-stimulating factor (G-CSF) is a naturally occurring chemical in the body that stimulates the production of neutrophils. Neupogen is a synthetic version of G-CSF. It binds to stem cells and stimulates the production of neutrophils, helping to decrease the risk of infection.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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