Cancer Home > Liposomal Vincristine Dosage

Available as an injection that is given into a vein, liposomal vincristine is administered by a healthcare provider in a healthcare setting once every seven days. Your height and weight are some of the factors your healthcare provider will use to calculate your recommended dosage of liposomal vincristine. However, if you develop dangerous side effects with this drug, you may need a lower amount.

An Introduction to Your Dosage of Liposomal Vincristine

The dose of liposomal vincristine sulfate (Marqibo®) your healthcare provider recommends will vary, depending on a number of factors, such as:
  • Your weight and height
  • How you tolerate the medication, such as if you experience side effects.
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.

Recommended Liposomal Vincristine Dosing Guidelines

Like many chemotherapy medications, liposomal vincristine doses are based on body surface area, which is calculated using your height and weight. Doses based on body surface area are written as milligrams per meter squared (mg per m2).
The recommended dosage of liposomal vincristine for the treatment of acute lymphoblastic leukemia is 2.25 mg per m2 once every seven days. Your healthcare provider will monitor you closely after each dose. If you experience potentially serious liposomal vincristine side effects, your healthcare provider may reduce your dosage, recommend a longer break between doses, or stop treatment altogether.

General Information on Using Liposomal Vincristine

Some considerations to keep in mind during treatment with liposomal vincristine include the following:
  • This medication comes in injectable form. It is usually given slowly into a vein (as an intravenous, or IV, infusion) once every seven days.
  • You will normally receive your liposomal vincristine dose in a healthcare setting, such as a hospital or infusion center. 
  • Each injection is given over approximately one hour.
  • Let your healthcare provider know right away if you experience redness, swelling, or burning at your IV site while receiving your infusion. These could be signs of a potentially serious problem.
  • Liposomal vincristine should only be given intravenously (as an IV). It may cause death if administered by other routes.
  • This medication can cause constipation. Make sure to drink plenty of fluids to stay well hydrated, unless your healthcare provider tells you otherwise. You may also need to increase your dietary fiber and take medicines to soften your stool (stool softeners).
  • For the medication to work properly, it must be taken as prescribed. This medication works best if taken on schedule; however, you may need an interruption in therapy if you develop certain side effects. 
  • If you are unsure about anything related to your dosage of liposomal vincristine, please talk with your healthcare provider, nurse, or pharmacist.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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