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Ketoconazole and phenobarbital are two of the medications that may interact with Kytril. Drug interactions with ketoconazole can increase the level of Kytril in your blood, which can lead to side effects. Phenobarbital can decrease the level of Kytril in your blood and make it less effective. To minimize your risk of developing drug interactions with Kytril, tell your healthcare provider about other medicines you are taking.

Kytril Drug Interactions: An Overview

Kytril® (granisetron hydrochloride) can potentially interact with a few other medications. Some of these medicines that may lead to Kytril interactions include:
 
  • Ketoconazole (Nizoral®)
  • Phenobarbital (Luminal®)
  • Medications that can cause a heart rhythm change known as QT prolongation (see QT-Prolonging Medications for a list of such medications).
      

Kytril Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Kytril is combined with any of the drugs listed above.
 
Ketoconazole (Nizoral)
Ketoconazole may decrease your body's ability to metabolize Kytril, which could increase the level of Kytril in your blood. This, in turn, could increase your risk of Kytril side effects. Talk to your healthcare provider before using ketoconazole and Kytril together.
 
Phenobarbital (Luminal)
Studies have shown that phenobarbital can decrease the level of Kytril in your blood by 25 percent, perhaps making it less effective. Your healthcare provider may need to adjust your Kytril dosage, although this may not be necessary.
 
QT-Prolonging Medications
There have been reports of a certain change in heart rhythm (known as QT prolongation) in people taking Kytril. This heart rhythm change can be dangerous. Check with your healthcare provider before combining Kytril with other QT-prolonging medications.
  
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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