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More Detail on Drug Interactions With Imatinib

The following sections explain in detail the potentially negative reactions that can occur when imatinib is combined with any of the drugs listed above.
Taking acetaminophen during imatinib treatment may increase your risk for liver toxicity. It is generally recommended that people who take this drug limit their acetaminophen use to no more than 1300 mg per day. Talk to your healthcare provider about using these medications together.
Combining imatinib with alfuzosin can increase alfuzosin blood levels, increasing your risk for potentially serious side effects. In most cases, these drugs should not be taken together.
Imatinib can increase the amount of almotriptan in your blood, possibly increasing your risk for side effects. Your healthcare provider may need to give you a lower almotriptan dosage, or a different medicine altogether, if you are taking imatinib.
Imatinib can increase the level of budesonide in your body, potentially increasing your risk for budesonide side effects. This interaction is more of a concern with budesonide capsules than with the inhaled formula. Your healthcare provider may choose to give you a lower budesonide dosage if you take it with imatinib.
Certain Statin Medications
Imatinib may increase the level of certain statin medications in the blood, increasing the risk for potentially serious side effects affecting the muscles. In general, people taking imatinib should not receive lovastatin or simvastatin.
Imatinib increases blood levels of colchicine, which could increase your risk for potentially serious colchicine side effects. Do not take these medications together without first talking to your healthcare provider. You may need a lower colchicine dosage.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
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