Gliadel® (carmustine implant) is a prescription medication used to treat certain types of brain tumors. Specifically, it is used in combination with surgery and radiation therapy to treat newly diagnosed malignant gliomas, which are brain tumors that are often referred to as "brain cancer." Gliadel is also approved for use in combination with surgery to treat glioblastoma multiforme that has returned after previous treatment.
Gliadel comes as small, dime-sized wafers that are surgically implanted into the brain. When used to treat cancerous brain tumors, Gliadel wafers are implanted into the brain in the space that remains after the brain tumor is surgically removed. Once implanted, the wafers begin to dissolve and release the active ingredient directly into the area.
(Click Gliadel Uses to learn more about using these wafers to treat cancerous brain tumors. This Web page offers detailed information on how this drug works, what it is used to treat, and whether it is safe for children.)
Written by/reviewed by: Kristi Monson, PharmD;Arthur Schoenstadt, MD
Last reviewed by: KristiMonson, PharmD;
List of references (click here):
Gliadel [package insert]. Woodcliff Lake, NJ: Eisai, Inc.;2010 April.
Gliadel Web site. Available at: http://www.gliadel.com/. Accessed August 4, 2012.
Louis DN, Schiff D, Batchelor T. Classification of gliomas. In: UpToDate, Basow, DS (Ed), UpToDate, Waltham, MA, 2012.
Wong Et and Wu JK. Clinical presentation and diagnosis of brain tumors. In: UpToDate, Basow, DS (Ed), UpToDate, Waltham, MA, 2012.
Batchelor T. High grade glioma in adults (beyond the basics). In: UpToDate, Basow, DS (Ed), UpToDate, Waltham, MA, 2012.
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