Cancer Home > Folotyn Uses

How Does It Work?

Folotyn works by inhibiting an enzyme known as dihydrofolate reductase. This enzyme is important for transforming an inactive form of folic acid into the active form, which is necessary to make some of the building blocks needed for DNA production. By inhibiting this enzyme, Folotyn interferes with the ability of cells, including cancer cells, to repair and replicate (copy) themselves.

Is It Safe for Children to Use Folotyn?

Folotyn has not been adequately studied in children, and is not approved for use in this age group (usually defined as individuals younger than 18 years old). Talk to your child's healthcare provider about the risks and benefits of using this medication in children.

Can Older Adults Use It?

In clinical trials, people age 65 and older responded no differently to Folotyn than people younger than this. However, some older adults may be more sensitive to the effects of this medication and may need to be monitored more closely during treatment.

Are There Off-Label Uses for Folotyn?

On occasion, a healthcare provider may recommend this medication for treating something other than peripheral T-cell lymphoma. This is called an "off-label" use. Possible off-label Folotyn uses may include treating other types of lymphoma, such as cutaneous T-cell lymphoma.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
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