Cancer Home > Folotyn Side Effects

If you are undergoing treatment with Folotyn and experience fever, unusual bleeding, or persistent vomiting, contact your healthcare provider right away. Serious problems can occur with this chemotherapy medication, so it is important to know which reactions require immediate medical treatment. Some of the more commonly reported side effects of Folotyn include nausea, sores in the mouth, and fatigue.

An Introduction to Folotyn Side Effects

Just like any chemotherapy medicine, Folotyn® (pralatrexate) can cause side effects, some of which can be quite significant. In fact, the majority of people who receive the medicine will develop some type of side effect during treatment. Speak with your healthcare provider about ways to prevent or lessen adverse reactions to this medicine.
 
(This article covers many, but not all, of the possible side effects with Folotyn. Your healthcare provider can discuss a more complete list with you.)
 

Common Side Effects With Folotyn

Folotyn has been studied extensively in clinical trials. In these studies, the side effects that occurred in a group of people using the drug were carefully documented. As a result, it was possible to see what side effects occurred and how often they appeared.
 
In clinical studies, the most common Folotyn side effects included:
 
  • Sores and swelling in the mouth -- in up to 70 percent of people
  • Low platelet counts (which could cause abnormal bruising and bleeding) -- up to 41 percent
  • Nausea -- up to 40 percent
  • Fatigue -- up to 36 percent
  • Anemia (low red blood cell counts) -- up to 34 percent
  • Constipation -- up to 33 percent
  • Fever -- up to 32 percent
  • Swelling of the arms, hands, legs, ankles, or feet -- up to 30 percent
  • Cough -- up to 28 percent
  • Nosebleeds -- up to 26 percent.
 
Other common reactions, occurring in 10 percent to 25 percent of people, included:
 
  • Vomiting
  • Decreased white blood cells (which could increase the risk for infection)
  • Diarrhea
  • Shortness of breath
  • Decreased appetite
  • Low levels of potassium in the blood (hypokalemia)
  • Rash
  • Itching
  • Sore throat
  • Elevated liver enzymes
  • Abdominal (stomach) pain
  • Arm or leg pain
  • Night sweats
  • Weakness or lack of energy
  • Increased heart rate
  • Upper respiratory tract infection, such as the common cold.
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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