Cancer Home > Fentanyl Sublingual Spray Dosage

Your healthcare provider will determine your dosage of fentanyl sublingual spray based on how you respond to the drug and other medical conditions you have, among other things. This prescription medication comes in the form of a liquid that is sprayed under the tongue. It is typically taken every four hours as needed for pain, but should not be used more than four times a day.

An Introduction to Your Dosage of Fentanyl Sublingual Spray

The dose of fentanyl sublingual spray (Subsys®) your healthcare provider recommends will vary, depending on a number of factors, including:
 
  • The type and severity of your pain
  • How you respond to the medication
  • Other medications you are taking
  • Other medical conditions you may have.
 
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.
 

Initial Fentanyl Sublingual Spray Dose

The initial dosage of fentanyl sublingual spray for treating breakthrough pain is 100 mcg, no matter how bad your pain or how high your dosage of other opioids. If this amount adequately relieves your pain, you should continue using the 100-mcg dosage for each breakthrough pain episode. If this amount does not adequately relieve your pain within 30 minutes, you may take one additional 100-mcg spray. You must then wait at least four hours before taking another dose.
 
Doses of fentanyl sublingual spray are not equivalent to doses of other fentanyl-containing medications. The initial dosage of fentanyl sublingual spray should be 100 mcg, even in people who are already taking another fentanyl medication. Starting fentanyl sublingual spray at a higher dosage could cause an overdose.
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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