Cancer Home > Drug Interactions With Fentanyl Sublingual Spray

Combining certain medications with fentanyl sublingual spray may result in potentially serious complications. Some of these reactions can increase your risk for side effects, such as drowsiness, memory loss, and difficulty breathing. Amphetamines, alcohol, and antipsychotic medications are some of the products that can lead to drug interactions with fentanyl sublingual spray.

An Overview of Fentanyl Sublingual Spray Interactions

Fentanyl sublingual spray (Subsys®) is a prescription narcotic pain medication used to treat breakthrough pain in people with cancer. This product may potentially react with many other medications.
 
Some of the drugs that may lead to fentanyl sublingual spray interactions include but are not limited to:
 
  • Alcohol
  • Alvimopan (Entereg®)
  • Amphetamines or amphetamine-like medications, such as:
 
 
 
 
 
 
  • CYP 3A4 inducer medications, such as:
 
 
  • CYP 3A4 inhibitor medications, such as:
 
 
  • Desmopressin (DDAVP®, Minirin®, Stimate®)
  • Grapefruit juice
  • Medications that cause drowsiness, such as:
 
 
  • Monoamine oxidase inhibitors (MAOIs), such as:
 
 
  • Octreotide (Sandostatin®)
  • Pegvisomant (Somavert®)
  • Thiazide diuretics (and thiazide-like diuretics), such as:
 
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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