Cancer Home > Drug Interactions With Etoposide Phosphate

Mifepristone
Mifepristone may increase the level of etoposide phosphate in your bloodstream, increasing your risk for side effects. This interaction is more likely to be a concern when mifepristone is taken on an ongoing basis, as opposed to one-time doses that are used to end an early pregnancy.
 
P-glycoprotein (Pgp) Inducers
P-glycoprotein is a protein in the body that helps remove substances, such as medications, from the tissues in the body so they can be removed through the urine or feces. Pgp helps remove etoposide phosphate from the body, and medications known as Pgp inducers increase the activity of Pgp.
 
Combining etoposide phosphate with one of these drugs causes etoposide phosphate to be removed from the body too quickly, potentially making it less effective. Your healthcare provider may choose to monitor you more closely if you use these medications together.
 
P-glycoprotein (Pgp) Inhibitors
P-glycoprotein is a protein in the body that helps remove substances, such as medications, from the tissues in the body so they can be removed through the urine or feces. Pgp helps remove etoposide phosphate from the body, and medications known as Pgp inhibitors decrease the activity of Pgp.
 
Combining etoposide phosphate with one of these drugs causes etoposide phosphate to be removed more slowly, increasing your risk for serious side effects. Your healthcare provider may choose to monitor you more closely for side effects if you use these medications together.
 
Pimozide
Etoposide phosphate may increase blood levels of pimozide, which could increase your risk for pimozide side effects. Talk to your healthcare provider before using these medicines together.
 
Roflumilast
Combining roflumilast with etoposide phosphate could make you more susceptible to infections. Talk to your healthcare provider about this potential interaction before using these medicines together.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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