Cancer Home > Drug Interactions With Etoposide Injection
Cyclosporine can significantly increase etoposide blood levels, which would increase your risk for potentially serious side effects. If you use these medicines together, your healthcare provider may choose to give you a lower etoposide injection dose.
CYP 3A4 Inducer Medications
The liver breaks down etoposide using enzymes known as CYP 3A4 enzymes, and medications known as CYP 3A4 inducers can increase the activity of these enzymes. Thus, combining etoposide injections with one of these drugs may decrease the level of etoposide in your bloodstream, making it less effective. Your healthcare provider may recommend you stop taking certain CYP 3A4 inducers before beginning etoposide injection treatment.
CYP 3A4 Inhibitor Medications
The liver breaks down etoposide using enzymes known as CYP 3A4 enzymes, and medications known as CYP 3A4 inhibitors can decrease the activity of these enzymes. Thus, combining etoposide injections with one of these drugs may increase the level of etoposide in your bloodstream, increasing your risk for side effects. Your healthcare provider may decrease your etoposide injection dose if you combine etoposide injections with a CYP 3A4 inhibitor.
Echinacea could make etoposide injections less effective. Do not take echinacea during etoposide injection treatment without first speaking with your healthcare provider.
Live vaccines are vaccines that contain live viruses or bacteria. Because you are more prone to infections, you could become infected with the virus or bacteria used to make the vaccine if you receive a live vaccine during etoposide injection treatment. Also, live vaccines may be less effective in people using etoposide injections. In general, people receiving etoposide injections should not receive live vaccines. Therefore, you should talk to your healthcare provider before receiving a vaccination.