Cancer Home > Duraclon Warnings and Precautions

Before you start treatment, warnings and precautions for Duraclon should be reviewed. This includes talking to your healthcare provider if you have depression, a bleeding disorder, or any allergies. Duraclon is not suitable for everyone; you should not use this drug if you have an infection at the site of administration or take anticoagulant medications.

What Should I Tell My Healthcare Provider Before Taking Duraclon?

You should talk with your healthcare provider prior to taking Duraclon® (clonidine hydrochloride) if you:
  • Have depression
  • Have a bleeding disorder
  • Are taking anticoagulant medications ("blood thinners")
  • Have any allergies, including allergies to food, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
Make sure to tell your healthcare provider about all other medicines you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Specific Duraclon Warnings and Precautions

Some warnings and precautions to be aware of prior to taking Duraclon include the following:
  • Duraclon is very likely to cause low blood pressure (hypotension) or other serious problems. For this reason, Duraclon should be reserved for treating severe pain in people with cancer. Only very rarely will the benefits of Duraclon outweigh the risks.
  • You should not abruptly stop taking Duraclon, as serious problems (including a stroke or even death) may result. Your healthcare provider will advise you about how to safely stop taking this medication. It is usually recommended to slowly reduce the dose over a period of at least two to four days, with careful monitoring. Let your healthcare provider know if you develop any problems while stopping Duraclon.
  • The active ingredient in Duraclon (clonidine) may increase the risk of depression.
  • Duraclon can potentially interact with a few other medications (see Duraclon Drug Interactions).
  • Duraclon is given through an epidural catheter (a small tube inserted into the spine). As with any epidural infusion, there is a possibility of developing a serious infection. Let your healthcare provider know if you have an unexplained fever, as this could be a sign of an infection.
  • Duraclon can cause dizziness and drowsiness. This may interfere with your ability to drive or operate heavy machinery.
  • Duraclon is considered a pregnancy Category C medication. This means that it might not be safe during pregnancy, although the full risks are not currently known (see Clonidine and Pregnancy).
  • Duraclon passes through breast milk in humans. Therefore, if you are breastfeeding or plan to start breastfeeding, discuss this with your healthcare provider prior to taking the drug (see Clonidine and Breastfeeding).
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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