Cancer Home > Drug Interactions With Clofarabine
The following sections explain in detail the potentially negative interactions that can occur when clofarabine is combined with any of the drugs listed above.
Combining amphotericin B with chemotherapy medicines like clofarabine may increase the risk for amphotericin B side effects, such as kidney damage, low blood pressure (hypotension), and lung problems. Your healthcare provider may choose to monitor you more closely if you use these medicines together.
Certain Biologic and Immunologic Medications
Using clofarabine with other medicines that suppress the immune system, such as certain biologic and immunologic medications, could increase your risk for potentially serious side effects, including low blood cell counts, infections, anemia, and bleeding problems. It is recommended that clofarabine not be used in combination with some biologic and immunologic drugs, while other combinations will require careful monitoring.
Taking clozapine with clofarabine may increase the risk for dangerously low white blood cells and potentially serious infections. Talk to your healthcare provider before using these medicines together. However, do not stop taking clozapine unless your healthcare provider specifically tells you to do so.
Clofarabine may cause your body to absorb less digoxin from the gastrointestinal (GI) tract, which could decrease the level of digoxin in your bloodstream. This interaction is thought to only be a potential problem with digoxin tablets, as opposed to other forms, such as digoxin solution (liquid). Your healthcare provider may choose to monitor your response to digoxin more closely if you use these medicines together.
Clofarabine may be less effective if it is used in combination with echinacea. Do not use these medications together without your healthcare provider's approval.
Live vaccines contain live viruses or bacteria. If you receive a live vaccine while using clofarabine, you might become infected with the virus or bacteria. Also, live vaccines may be less effective in people receiving clofarabine. In general, people who are undergoing chemotherapy treatment are advised to not receive a live vaccination. Talk to your healthcare provider before receiving a vaccination or immunization during clofarabine treatment.
Medications That May Cause Kidney Damage
The manufacturer of clofarabine recommends that medications with the potential to damage the kidneys not be used during the five-day treatment period. Many medications are associated with potential kidney damage. Therefore, you should ask your healthcare provider about any particular medication you are considering taking, including prescription and nonprescription medicines.
Medications That May Cause Liver Damage
The manufacturer of clofarabine recommends that medications with the potential to damage the liver not be used during the five-day treatment period. Many medications are associated with potential liver damage. Therefore, you should ask your healthcare provider about any particular medication you are considering taking, including prescription and nonprescription medicines.
Combining roflumilast with clofarabine may further increase your risk for developing infections. Talk to your healthcare provider about this potential interaction before using these drugs together.
Clofarabine could decrease the effectiveness of sipuleucel-T. This is because sipuleucel-T is thought to work by stimulating the body's immune system, while clofarabine decreases the activity of the immune system. Talk to your healthcare provider about this possible interaction before using these medicines together.
Chemotherapy medicines, such as clofarabine, have been reported to both increase and decrease the effects of warfarin. If you take these drugs together, your healthcare provider may need to monitor your prothrombin time ("protime" or PT) and international normalized ratio (INR) more closely than usual, and adjust your warfarin dosage if needed.