Cancer Home > Clofarabine

Important Information for Your Healthcare Provider

You should talk with your healthcare provider prior to receiving this medication if you have:
 
  • Liver disease, such as hepatitis, cirrhosis, or liver failure
  • Kidney disease, such as kidney failure (renal failure)
  • Received a hematopoietic stem cell transplant
  • Any allergies, including to foods, dyes, or preservatives.
 
Also, let your healthcare provider know if you are:
   
Make sure to tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
 
(Click Precautions and Warnings With Clofarabine to learn more, including information on who should not receive the drug.)
 

How Does It Work?

Clofarabine works to treat leukemia in a couple of different ways. The drug enters cells, where it prevents DNA from replicating. Because DNA replication is necessary for cancer cells to divide, clofarabine can block the growth of the leukemia cells.

It also damages the mitochondrial membrane, which is an important part of the cell that provides it with usable energy. By damaging this vital cell structure, clofarabine can cause leukemia cells to die.
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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