Cancer Home > Clofarabine Dosage

The amount of clofarabine your healthcare provider prescribes will be determined based on how much you weigh, how you respond to the medication, and other factors. This drug is given as an injection into a vein. Clofarabine dosing regimens call for the medicine to be given once a day for five days in a row, with additional treatment cycles every two to six weeks.


An Introduction to Your Dosage of Clofarabine

The dose of clofarabine (Clolar®) your healthcare provider recommends will vary, depending on your height and weight and how you respond to the medication. As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.

Recommended Clofarabine Dosing Guidelines

Like many chemotherapy medicines, clofarabine dosing is based on body surface area (BSA), which is normally calculated using a person's height and weight. Doses based on body surface area are written as mg per meter squared (mg per m2).
The usual recommended dose of clofarabine for the treatment of acute lymphoblastic leukemia in children age 1 to 21 years old is 52 mg per m2 daily for five days. This is one treatment cycle.
Your healthcare provider may recommend additional treatment cycles every two to six weeks, based on how you respond to and tolerate the medication. If you will be receiving more treatment cycles, they will begin once you have adequately recovered from any side effects caused by the previous treatment cycle, but no sooner than two weeks after your last dose. If you experience potentially serious clofarabine side effects, your healthcare provider may reduce the dosage of your next treatment cycle.

General Information on Using Clofarabine

Some considerations to keep in mind during treatment with clofarabine include the following:
  • This medication comes in the form of a liquid that is given as a slow injection into a vein (an intravenous, or IV, infusion). It is usually given once a day for five days in a row every two to six weeks.
  • It will take about two hours to receive each clofarabine dose.
  • Clofarabine injections are normally given by a healthcare provider in a healthcare setting, such as a hospital or clinic, where you can be closely monitored.
  • You will receive IV fluids and other medications throughout each five-day treatment cycle to help reduce the risk for certain clofarabine side effects.
  • Your healthcare provider may also recommend other medicines, such as medications for nausea and vomiting, steroids, or antibiotics, to help reduce or prevent side effects.
  • You should drink plenty of fluids during treatment to stay hydrated.
  • Let your healthcare provider know right away if you feel anxious during the clofarabine infusion. He or she can slow down the infusion, which may help reduce the anxiety
  • For the medication to work properly, it must be used as prescribed. It is important to keep all of your appointments to receive clofarabine.
  • If you are unsure about anything related to your clofarabine dosage, please talk with your healthcare provider or pharmacist.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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