Clofarabine (Clolar®) is a medication available by prescription only and approved to treat acute lymphoblastic leukemia (ALL). This type of cancer affects bone marrow and certain blood cells. This drug is approved for use in children and young adults age 1 to 21 years old.
Clofarabine works to treat this cancer by preventing DNA from replicating, which is necessary for cancer cells to divide. Because DNA must replicate to divide, this medicine slows down the growth of cancer cells and may even cause the cancer cells to die.
There may also be times when a healthcare provider prescribes clofarabine to treat other conditions, such as acute myelocytic leukemia and myelodysplastic syndrome; however, these are unapproved ("off-label") uses for the medication.
(Click What Is Clofarabine Used For? for more details on using this anticancer drug to treat acute lymphoblastic leukemia. This full-length article describes how this drug works and whether it is safe for use in adults.)
Written by/reviewed by: Kristi Monson, PharmD;Arthur Schoenstadt, MD
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