Cancer Home > CeeNU Overdose

Dangerous reactions may occur if someone takes too much CeeNU (lomustine). Possible overdose effects may include serious infections, bleeding, and even death. The specific effects will depend on how much was taken, whether it was combined with other drugs, and other factors. Some of the ways to treat this type of overdose include administering activated charcoal, pumping the stomach, and providing supportive care.

Can You Take Too Much CeeNU?

CeeNU® (lomustine) is a prescription chemotherapy medication that belongs to a group of drugs known as alkylating agents. Specifically, it is classified as a nitrosourea alkylating agent. CeeNU is approved to treat cancerous brain tumors and Hodgkin's disease. It may also be used off-label to treat other cancers.
 
As with most medicines, it is possible to take too much CeeNU. The specific effects of an overdose can vary, depending on a number of factors, such as the CeeNU dosage and whether it was taken with any other medications or substances.
 

Effects of an Overdose

An overdose with this medicine can be extremely dangerous. Based on reports of accidental overdoses with CeeNU, possible symptoms may include but are not limited to:
 
  • Bone marrow suppression, which could cause:
 
    • Infections due to low white blood cells
    • Bleeding due to low platelets
    • Anemia due to low red blood cells
 
  • Abdominal (stomach) pain
  • Diarrhea
  • Vomiting
  • Loss of appetite
  • Lethargy
  • Dizziness
  • Cough
  • Shortness of breath
  • An enlarged liver
  • Increased liver enzymes, which could be a sign of liver damage
  • Enlarged lymph nodes
  • Inflammation of the small intestines
  • Changes in mental awareness
  • Abnormal rapid breathing
  • Death.
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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