Cancer Home > What Is Busulfan Injection Used For?

Busulfan injection is prescribed to prepare the body for a stem cell transplant. It helps destroy cancer cells in people who have a certain type of cancer called chronic myelogenous leukemia. After using busulfan injection, stem cells are given through an intravenous infusion, where they help replace the body's blood cells.

An Overview of Uses for Busulfan Injection

Busulfan injection (Busulfex®) is a prescription medication approved to prepare the body for a stem cell transplant in people with chronic myelogenous leukemia. It is used in combination with a medication known as cyclophosphamide (Cytoxan®).

What Is Chronic Myelogenous Leukemia?

Chronic myelogenous leukemia (also called chronic myeloid leukemia, chronic myelocytic leukemia, chronic granulocytic leukemia, or just CML) is a slowly progressing cancer of the blood cells. It is one of several kinds of leukemia (see Types of Leukemia for more information).
Normally, the bone marrow (the spongy center of certain bones in the body) makes immature blood cells called stem cells. Blood stem cells become mature white blood cells, red blood cells, and platelets. However, in CML, too many stem cells become a type of white blood cell known as a granulocyte. These granulocytes are abnormal and do not work like regular white blood cells.
As the number of abnormal granulocytes increases, they may crowd out healthy, normal blood cells. This can lead to problems such as:
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Last reviewed by: Kristi Monson, PharmD;
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