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More Detail on Drug Interactions With Busulfan Injection

The following sections explain in detail the potentially negative interactions that can occur when busulfan injection is combined with any of the drugs listed above.
 
Acetaminophen
Acetaminophen may increase blood levels of busulfan injection, potentially increasing the risk for side effects. Let your healthcare provider know if you take any product containing acetaminophen during treatment or in the three days before you begin to receive your busulfan injection doses.
 
Amphotericin B
Combining certain chemotherapy medicines, including busulfan injection, with amphotericin B could increase the risk for potentially serious amphotericin B side effects, such as low blood pressure (hypotension) and lung problems. Your healthcare provider may choose to closely monitor you for side effects if you use these medicines together.
 
Biologic and Immunologic Medications
Taking certain biologic and immunologic medicines during busulfan injection treatment could increase the risk for potentially serious side effects, including infections, anemia, and possibly the development of other cancers. Busulfan injection should not be used in combination with some biologic or immunologic medicines, while other combinations will require careful monitoring. Talk to your healthcare provider about this potential interaction if you are taking biologic or immunologic medicines.
 
Clozapine
Using clozapine and busulfan injection together may cause dangerously low white blood cell counts and increase your risk for potentially life-threatening infections. Talk to your healthcare provider about this potential interaction if you take clozapine. Do not stop taking clozapine, however, unless your healthcare provider specifically tells you to do so.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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