Cancer Home > Busulfan Injection

Busulfan injection is given intravenously four times a day for four days to help prepare the body for a stem cell transplant. This prescription chemotherapy drug is specifically designed for people who have a type of cancer called chronic myelogenous leukemia. Most people who receive this medicine will develop some type of side effect, such as infections, nausea, and mouth sores.

What Is Busulfan Injection?

Busulfan injection (Busulfex®) is a prescription medication approved to prepare the body for a stem cell transplant, specifically in people with chronic myelogenous leukemia (also called chronic myeloid leukemia). It is used in combination with another medication called cyclophosphamide (Cytoxan®). Busulfan injection is in a class of drugs known as alkylating agents.
(Click What Is Busulfan Injection Used For? for more information on this topic, including possible off-label uses.)

Are There Side Effects?

Just like any chemotherapy medicine, busulfan injection can cause side effects, some of which can be significant and potentially serious. In fact, most people will experience some type of side effect during treatment. Talk with your healthcare provider about ways to prevent or lessen reactions to this drug.
Possible side effects of busulfan injection include but are not limited to:
  • Decreased white blood cells, which could increase the risk for infections
  • Decreased red blood cells (anemia)
  • Decreased platelets, which could increase the risk for bleeding
  • Nausea
  • Mouth sores.
(Click Busulfan Injection Side Effects to learn more, including potentially serious side effects you should report immediately to your healthcare provider.)
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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