Cancer Home > Busulfan Injection Dosage

When prescribing busulfan injection, the dosage will vary for each person, depending on his or her weight, response to the medication, and existing medical conditions. This injection is given slowly into a vein four times a day for four days. It takes about two hours for each infusion, which will be administered by a healthcare provider in a healthcare setting.

An Introduction to Your Dosage of Busulfan Injection

The dose of busulfan injection (Busulfex®) your healthcare provider recommends will vary, depending on a number of factors, including:
  • Your weight
  • How you respond to and tolerate the medication
  • Other medical conditions you may have
  • Other medications you are taking.
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.

Recommended Busulfan Injection Dosing Guidelines

The usual recommended dose of busulfan injection prior to a stem cell transplant is 0.8 mg per kg body weight (about 0.36 mg per lb), given every six hours for four days (a total of 16 doses). People who are obese may receive amounts based on what is known as their adjusted ideal body weight, as opposed to their actual weight. In some cases, doses may be adjusted based on busulfan injection blood levels.
Busulfan injection is normally used as part of a treatment regimen that includes cyclophosphamide (Cytoxan®). The first dose of cyclophosphamide is usually given six or more hours after the last dose of busulfan injection three days before the stem cell transplant.

General Information on Using Busulfan Injection

Some considerations to keep in mind during treatment with busulfan injection include the following:
  • This medicine comes as a liquid that is given as an injection into a vein (an intravenous, or IV, injection). It is usually given four times a day for four days.
  • The injection is given by a trained healthcare provider in a healthcare setting, such as a hospital or clinic.
  • It will take about two hours to receive your busulfan injection.
  • Busulfan injection can be irritating to the skin. Tell your healthcare provider immediately if you have pain, redness, or swelling at the IV site (the site where the needle goes into your vein).
  • For this drug to work properly, it must be used as prescribed.
  • If you are unsure about anything related to your busulfan injection dosage, please talk with your healthcare provider or pharmacist.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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